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Idarucizumab is a monoclonal antibody fragment that specifically binds dabigatran and its metabolites. When vitamin K is given IV, it should be administered by slow infusion to minimize risk of anaphylaxis.Īnswer B is incorrect because the reversal agent for dabigatran is idarucizumab (Praxbind). Normally, it is given when INR is > 10 and/or significant bleeding is present. Tulsa (OK): Educational Concepts, L.L.C.Which of the following correctly matches the drug with its antidote/reversal agent? Select all that apply.īecause warfarin is a vitamin K antagonist, phytonadione (vitamin K) can be given as an antidote, making answer A correct. Saunders Handbook of Veterinary Drugs: Small and Large Animal. Labrador & Golden Retrievers, German Shepherd Cumulative toxic doses of warfarin have been reported as 1-5 mg/kg for 5 to 15 days in dogs and 1 mg/kg for 7 days in cats. Toxic consumption: In both dogs and cats, doses of 5-50 mg/kg have been associated with toxicity. Due to the nature of warfarin’s mechanism of action, it may take 2-5 days before signs of toxicity occur. Signs and symptoms of toxicity: extreme fatigue, refusal to eat, bloody urine, and vomiting. It could, therefore, take 2-5 days before signs of toxicity occur. It’s important to note that a lag time occurs after warfarin is ingested. Current evidence is controversial, but not recommended.ĭespite it’s use in veterinary medicine, acute overdosages of warfarin may result in life-threatening hemorrhage. In dogs, it is used primarily for long-term thromboprophylaxis. Warfarin is an anticoagulant used in both human and veterinary medicine.